Neupogen is a 175 amino acid protein manufactured by recombinant dna technology. Filgrastim hexal is available in packs containing 1, 3, 5 or 10 prefilled syringes with injection needle and with or without a needle safety guard. Be sure you know how long you can leave filgrastim injection at room temperature before you need to throw it away. Giving yourself an injection of filgrastim neupogen or. Patient package insert 29 may 2002 neupogen filgrastim. Filgrastim definition of filgrastim by medical dictionary. From here, you can crop your screenshot, resize it, and position it. Filgrastimsndz zarxio national drug monograph september 2016. The suggested filgrastim dose for preventing infections due to chemotherapy is 5 mcg per kg of weight daily. The dosing schedule and dosage of rituximab were not specified in the protocol.
The transfer of filgrastim into human milk has been documented in published literature. The following is the recommended dosage and frequency when administering this drug. Gcsf neupogen or filgrastim, granulocytecolony stimulating factor, is a glycoprotein that has multiple functions in both physiological and pathophysiological conditions. If taking filgrastim while pregnant, it is possible that traces of the drug could be found in the babys blood. To keep a pdf file as a support document for your presentation insert the entire pdf into the presentation as an object that you can open and view during your presentation. These highlights do not include all the information needed to. Projected place in therapy product licensed filgrastim sndz has been shown to be biosimilar the reference filgrastim in the u.
Yes, 3 new, phase iii clinical trials evaluated the efficacy of tbo filgrastim. Filgrastim was administered to monkeys dogs hamsters rats and mice as part of a preclinical toxicology program which included singledose acute repeateddose subacute subchronic and chronic studies. Filgrastim pegfilgrastim biosimilars biosuperiors 2015 a g. Open the ppt and go on the slide that you want to insert a pdf into click insert object object from file. If needed, filgrastim injection can be left out at room temperature for some time. Filgrastim ratiopharm are supplied in packs of 1, 5 or 10 prefilled syringes or multipacks of 10 2 packs of 5 prefilled syringes. Insert pdf file content into a powerpoint presentation. Filgrastim, lenograstim, nartograstim, pegfilgrastim. Treatment with filgrastim was initiated after a median of 22 months from the start of imatinib. Navigate and choose the pdf file and press insert and then. It is usually given once a day, but filgrastim injection products neupogen, nivestym, zarxio may be given twice a day when it is used to treat severe chronic neutropenia. Mar 15, 2020 filgrastim is injected under the skin or as an infusion into a vein.
The package insert instructions for dosage and duration of treatment should not be exceeded. It is not known if the drug can get into human breast milk. Filgrastim is a clear liquid that is injected under your skin or into a vein. How to add hyperlinks to a powerpoint presentation for. Package insert lists common adverse reactions from reference labeling. Iv filgrastim only nursing considerations first dose should be administered at least 24 hours after chemotherapy avoid use 24 hours before chemotherapy is administered neupogen filgrastim package insert. Learn how to insert objects in microsoft powerpoint at get the complete tutorial free. There are 2 other randomized controlled trials comparing tbo filgrastim with a european filgrastim product in patients. Highlights of prescribing information these highlights. Find patient medical information for filgrastim injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Open your powerpoint presentation on the page you want to insert the pdf within. Zarxio filgrastimsndz injection, for subcutaneous or intravenous use initial u. Filgrastim has not been studied in pregnant women and its effects on the fetus is unknown. This process will then insert a screenshot of your open pdf document window into the powerpoint presentation. Filgrastim ratiopharm is a solution for injection or infusion in a prefilled syringe.
Product monograph prneupogen filgrastim sterile solution. Other recombinant filgrastim products are poorly secreted into breast milk, and filgrastim is not orally absorbed by neonates. Gcsf filgrastim has also been used after chemotherapy for myeloid and lymphoid hematologic malignancies in adults, thus showing the feasibility and safety of the drug in this setting. This emedtv article also lists filgrastim dosing guidelines for bone marrow transplants, stem cell collection, and severe chronic neutropenia. Overall, filgrastimsndz is available in 2 dosage strengths300 mcg0. Filgrastim injection is used to treat neutropenia low white blood cells that is caused by cancer medicines. To enter and activate the submenu links, hit the down arrow. Click on the thumbnail that shows your open pdf document to select it. Highlights of prescribing information these highlights do not include all the information needed to use neupogen safely and effectively. Filgrastim hexal is a clear, colourless to slightly yellowish solution for injection or infusion in a prefilled syringe. With filgrastim, its important to watch for potentially dangerous drug interactions and take blood tests regularly to measure neutrophil levels in your blood.
Check with your physician if you have any of the following. Pediatric patients weighing less than 45kg the neulasta prefilled syringe is not designed to allow for direct administration of doses less than 0. Read more i understand that some in australia are getting subsidized filgrastim neupogen, hopefully you wont need it but id be discussing with my specialist so you. Reactions have included anaphylaxis see warnings and precautions 5. These highlights do not include all the information needed to use zarxio safely and effectively. Filgrastim vials and prefilled syringes do not contain the same concentrations of this medicine. The number of days you receive filgrastim will be prescribed by your doctor. Filgrastim helps the bone marrow to make new white blood cells. Zarxio filgrastimsndz dose, indications, adverse effects. The drug is available under generic name filgrastim and brand names filcad, imumax, neukine, neupogen, grafeel, emgrast, religrast, zarzio or zarxio and nufil.
Comparable efficacy and safety profiles of oncepercycle. Looking for great a pdf editing software to edit your pdfs on mac you want to read, annotate and edit pdfs, change text and images, fill forms and sign contracts like never before. What filgrastim hexal looks like and contents of the pack. Singledose administration of filgrastim by the oral. The pivotal trial compared tbo filgrastim with a european filgrastim product and placebo in patients with breast cancer. The following conditions are contraindicated with this drug. Metaanalysis and indirect treatment comparison of lipegfilgrastim. A sustainedduration form of filgrastim, pegfilgrastim, has been developed to. Here, we examine, whether a combination of pegfilgrastim and filgrastim exerts a benefit compared to filgrastim alone in safety and efficiency of autologous stem cell mobilization. Escherichia coli e coli bacteria into which has been inserted the human granulocyte colonystimulating factor gene.
You will now be able to tab or arrow up or down through the submenu options to accessactivate the submenu links. Use your thumb whichever thumb is more comfortable to slowly push the plunger all the way down. Make sure you understand the package directions and feel comfortable with the injections. Combine files into a single pdf, insert a pdf into another pdf, insert a clipboard selection into a pdf, or place insert a pdf as a link in another file. Unfortunately, inserting pdf content is not possible when editing a presentation in powerpoint for the web. Filgrastim injection products come as a solution liquid in vials and prefilled syringes to inject under the skin or into a vein. Whereas both filgrastim, and its long er acting pegylated form, pegfilgrastim, act only on progenitor cells that are already committed to one pathway, thus increasing only the neutrophil i.
Powerpoint 2016 tutorial inserting objects microsoft. If your pdf is in a presentation format, the conversion should be no problem. Filgrastim ratiopharm is a clear and colourless solution. Bmt recommended dose following bmt is 10 mcgkgday given as an iv infusion of 4 or 24 hours or sc. If neither of those two methods work for your needs, you can also add a pdf file into a powerpoint presentation as an action. Remove from refrigerator 30 minutes before injection.
The package insert for ribavirin recommends reducing the ribavirin dose at hemoglobin levels less than 10 gdl and permanently discontinuing the drug at levels less than 8. Combine or merge files into a single pdf, adobe acrobat dc. Insert the needle into your skin in one quick motion at a 90degree straight up and down angle see figure 3. The duration of followup differs among the studies. How to insert pdf into microsoft powerpoint presentation in windows 2018 how to insert pdf into microsoft powerpoint presentation easily. Jan 07, 2020 if filgrastim injection freezes, let it thaw in the refrigerator before use. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Hit enter to expand a main menu option health, benefits, etc. Filgrastim may be given subcutaneous the layer between the skin and muscle injection or infused into a vein intravenous, iv. To bring you great quality, smallpdf has partnered with solid documents that offers the best conversion out there. Other considerations do not administer to patients with latex allergy. Neupogen filgrastim injection, for subcutaneous or. It is a synthetic manmade form of a substance that is naturally produced in your body called a colony stimulating factor. Neulasta, inn pegfilgrastim european medicines agency. How to crop pictures in word, excel, and powerpoint 2010. See full prescribing information for recommended dosage adjustments and timing. Gcsf stimulates the bm to produce granulocytes and stem cells and release them into the bloodstream. Highlights of prescribing information neulasta safely and. Neupogen is produced in e coli the product is nonglycosylated and thus differs.
Follow these steps to use adobe acrobat to combine or merge word, excel, powerpoint, audio, or video files, web pages, or existing pdfs. Granulocyte colonystimulating factor gcsf has been shown to ameliorate myelosuppression in adults when administered after cancer chemotherapy. Filgrastim injection neupogen is a human granulocyte colonystimulating factor gcsf produced by recombinant dna technology. Neupogen in patients with serious allergic reactions. Neulasta is contraindicated in patients with a history of serious allergic reactions to pegfilgrastim or filgrastim. Pegfilgrastim has been subjected to preclinical studies, which are valid both on a standalone basis and also as a bridge to the nonpegylated product filgrastim. The effect of filgrastim or pegfilgrastim on survival outcomes of. However, no adverse effects in breastfeeding infants have been noted. Granulocyte colonystimulating factor filgrastim in. Neupogen is indicated to decrease the incidence of infection as manifested by febrile neutropenia in patients with nonmyeloid malignancies receiving. Neupogen filgrastim injection, for subcutaneous or intravenous use initial u.
Before starting a new medication, make sure you are aware of the drugs precautions and warnings. The needle cap on the prefilled syringes contains dry natural rubber derived from latex. The effects of filgrastim on human milk production are unknown. What is filgrastim filgrastim is a synthetic pharmaceutical analogue of naturally occurring granulocyte colonystimulating factorgcsf. Putting hyperlinks into powerpoint presentations links a slide to another slide in the same or another presentation, or to a web site, an email address, or another file.
If you are giving your own injection at home, use filgrastim exactly as directed by your doctor. It is indicated to decrease the incidence of infection as manifested by febrile neutropenia in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a significant incidence of severe neutropenia with fever. Local coverage determination for gcsf filgrastim, neupogen. Compared with pegfilgrastim or filgrastim, lipegfilgrastim has a statistically significantly. Do not use if filgrastim injection has been frozen more than once. Filgrastim injection route description and brand names. Neupogen is indicated in adult and pediatric patients with cancer receiving. Research article a combination of pegfilgrastim and.
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